Citation Impact
2.05 - 2-year Impact Factor
2.505 - 5-year Impact Factor
0.689 - Source Normalized Impact per Paper (SNIP)
1.109 - SCImago Journal Rank (SJR)
Usage
852,052 downloads
Social Media Impact
523 mentions
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It was highlighted that the original article [1] contained errors in the figures and their legends and by extension the in-text figure citations. This Corrections article shows the correct figures and correct ...
Citation: BMC Systems Biology 2019 13:40
Characterization of drug-protein interaction networks with biological features has recently become challenging in recent pharmaceutical science toward a better understanding of polypharmacology.
Citation: BMC Systems Biology 2019 13(Suppl 2):39
The topological landscape of gene interaction networks provides a rich source of information for inferring functional patterns of genes or proteins. However, it is still a challenging task to aggregate heterog...
Citation: BMC Systems Biology 2019 13(Suppl 2):38
Systematic fusion of multiple data sources for Gene Regulatory Networks (GRN) inference remains a key challenge in systems biology. We incorporate information from protein-protein interaction networks (PPIN) i...
Citation: BMC Systems Biology 2019 13(Suppl 2):37
Major alteration in lifestyle of human population has promoted Type 2 diabetes mellitus (T2DM) to the level of an epidemic. This metabolic disorder is characterized by insulin resistance and pancreatic β-cell dys...
Citation: BMC Systems Biology 2019 13(Suppl 2):36
Flow cytometry is a popular technology for quantitative single-cell profiling of cell surface markers. It enables expression measurement of tens of cell surface protein markers in millions of single cells. It ...
Citation: BMC Systems Biology 2019 13(Suppl 2):35
Improving efficiency of disease diagnosis based on phenotype ontology is a critical yet challenging research area. Recently, Human Phenotype Ontology (HPO)-based semantic similarity has been affectively and wi...
Citation: BMC Systems Biology 2019 13(Suppl 2):34
Anti-tumor necrosis factor alpha (TNF- α) therapy has made a significant impact on treating psoriasis. Despite these agents being designed to block TNF- α activity, their mechanism of action in the remission of p...
Citation: BMC Systems Biology 2019 13(Suppl 2):29
Single-cell RNA sequencing (scRNAseq) data always involves various unwanted variables, which would be able to mask the true signal to identify cell-types. More efficient way of dealing with this issue is to ex...
Citation: BMC Systems Biology 2019 13(Suppl 2):28
Identification of Hürthle cell cancers by non-operative fine-needle aspiration biopsy (FNAB) of thyroid nodules is challenging. Resultingly, non-cancerous Hürthle lesions were conventionally distinguished from...
Citation: BMC Systems Biology 2019 13(Suppl 2):27
Biological experiments have confirmed the association between miRNAs and various diseases. However, such experiments are costly and time consuming. Computational methods help select potential disease-related m...
Citation: BMC Systems Biology 2019 13(Suppl 2):26
Numerous experimental results have indicated that microRNAs (miRNAs) play a vital role in biological processes, as well as outbreaks of diseases at the molecular level. Despite their important role in biologic...
Citation: BMC Systems Biology 2019 13:33
Adaptation and homeostasis are basic features of information processing in cells and seen in a broad range of contexts. Much of the current understanding of adaptation in network modules/motifs is based on the...
Citation: BMC Systems Biology 2019 13:32
Citation: BMC Systems Biology 2019 13:31
One of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may i...
Citation: BMC Systems Biology 2019 13:30
Microscopic images are widely used in plant biology as an essential source of information on morphometric characteristics of the cells and the topological characteristics of cellular tissue pattern due to mode...
Citation: BMC Systems Biology 2019 13(Suppl 1):22
Citation: BMC Systems Biology 2019 13(Suppl 1):21
A cancer cell line originating from human epithelial colorectal adenocarcinoma (Caco-2 cells) serves as a high capacity model for a preclinical screening of drugs. Recent need for incorporating barrier tissue ...
Citation: BMC Systems Biology 2019 13(Suppl 1):19
The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke v...
Citation: BMC Systems Biology 2019 13(Suppl 1):17
The JAK/STAT signaling pathway is involved in many aging-related cellular functions. However, effects of overexpression of genes controlling JAK/STAT signal transduction on longevity of model organisms have no...
Citation: BMC Systems Biology 2019 13(Suppl 1):16
Movement of populations on fitness landscapes has been a problem of interest for a long time. While the subject has been extensively developed theoretically, reconciliation of the theoretical work with recent ...
Citation: BMC Systems Biology 2019 13:25
A positive energy balance is considered to be the primary cause of the development of obesity-related diseases. Treatment often consists of a combination of reducing energy intake and increasing energy expendi...
Citation: BMC Systems Biology 2019 13:24
Iron plays crucial roles in the metabolism of eukaryotic cells. Much iron is trafficked into mitochondria where it is used for iron-sulfur cluster assembly and heme biosynthesis. A yeast strain in which Mrs3/4...
Citation: BMC Systems Biology 2019 13:23
Citation: BMC Systems Biology 2019 13:20
Clinical integration of systems biology approaches is gaining in importance in the course of digital revolution in modern medicine. We present our results of the analysis of an extended mathematical model desc...
Citation: BMC Systems Biology 2019 13:18
Understanding what determines the between-host variability in infection dynamics is a key issue to better control the infection spread. In particular, pathogen clearance is desirable over rebounds for the heal...
Citation: BMC Systems Biology 2019 13:15
It was highlighted that the original article [1] contained a mistake in the grant number in the Funding section of the Declarations, and in the legend of Fig. 6. This Correction article shows the incorrect and...
Citation: BMC Systems Biology 2019 13:14
It was highlighted that the original article [1] contained a typesetting error in the last name of Allon Canaan. This was incorrectly captured as Allon Canaann in the original article which has since been upda...
Citation: BMC Systems Biology 2019 13:13
Cholesterylester transfer protein (CETP) modulates the composition of various lipoproteins associated with cardiovascular disease. Despite its central role in lipoprotein metabolism, its mode of action is stil...
Citation: BMC Systems Biology 2019 13:12
There is little published regarding metabolism of Salinispora species. In continuation with efforts performed towards this goal, this study is focused on new insights into the metabolism of the three-identified s...
Citation: BMC Systems Biology 2019 13:11
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is a multifactorial disease with no definite diagnostic index. The aim of this study is to construct a molecular network to ...
Citation: BMC Systems Biology 2019 13:10
Liver has the unique ability to regenerate following injury, with a wide range of variability of the regenerative response across individuals. Existing computational models of the liver regeneration are largel...
Citation: BMC Systems Biology 2019 13:9
Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have bee...
Citation: BMC Systems Biology 2019 13:8
The Notch signaling pathway is involved in cell fate decision and developmental patterning in diverse organisms. A receptor molecule, Notch (N), and a ligand molecule (in this case Delta or Dl) are the central...
Citation: BMC Systems Biology 2019 13:7
Cells use signaling protein networks to sense their environment and mediate specific responses. Information about environmental stress is usually encoded in the dynamics of the signaling molecules, and qualita...
Citation: BMC Systems Biology 2019 13:6
The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. vivax h...
Citation: BMC Systems Biology 2019 13:5
A recurrent problem in genome-scale metabolic models (GEMs) is to correctly represent lipids as biomass requirements, due to the numerous of possible combinations of individual lipid species and the correspond...
Citation: BMC Systems Biology 2019 13:4
The formation of acetate by fast-growing Escherichia coli (E. coli) is a commonly observed phenomenon, often referred to as overflow metabolism. Among various studies that have been carried over decades, a recent...
Citation: BMC Systems Biology 2019 13:3
Genome-scale models of metabolism and macromolecular expression (ME models) enable systems-level computation of proteome allocation coupled to metabolic phenotype.
Citation: BMC Systems Biology 2019 13:2
Aggregation of high-throughput biological data using pathway-based approaches is useful to associate molecular results to functional features related to the studied phenomenon. Biological pathways communicate ...
Citation: BMC Systems Biology 2019 13:1
Evaluating the significance for a group of genes or proteins in a pathway or biological process for a disease could help researchers understand the mechanism of the disease. For example, identifying related pa...
Citation: BMC Systems Biology 2018 12(Suppl 9):141
One of the important steps in the process of assembling a genome sequence from short reads is scaffolding, in which the contigs in a draft genome are ordered and oriented into scaffolds. Currently, several sca...
Citation: BMC Systems Biology 2018 12(Suppl 9):139
Predicting disease causative genes (or simply, disease genes) has played critical roles in understanding the genetic basis of human diseases and further providing disease treatment guidelines. While various co...
Citation: BMC Systems Biology 2018 12(Suppl 9):138
During the identification of potential candidates, computational prediction of drug-target interactions (DTIs) is important to subsequent expensive validation in wet-lab. DTI screening considers four scenarios...
Citation: BMC Systems Biology 2018 12(Suppl 9):136
Drug repositioning is a promising and efficient way to discover new indications for existing drugs, which holds the great potential for precision medicine in the post-genomic era. Many network-based approaches...
Citation: BMC Systems Biology 2018 12(Suppl 9):134
Hot spot residues are functional sites in protein interaction interfaces. The identification of hot spot residues is time-consuming and laborious using experimental methods. In order to address the issue, many...
Citation: BMC Systems Biology 2018 12(Suppl 9):132
Discovering reliable protein biomarkers is one of the most important issues in biomedical research. The ELISA is a traditional technique for accurate quantitation of well-known proteins. Recently, the multiple...
Citation: BMC Systems Biology 2018 12(Suppl 9):123
Evidences have increasingly indicated that lncRNAs (long non-coding RNAs) are deeply involved in important biological regulation processes leading to various human complex diseases. Experimental investigations...
Citation: BMC Systems Biology 2018 12(Suppl 9):122
MicroRNA (miRNA) plays a key role in regulation mechanism of human biological processes, including the development of disease and disorder. It is necessary to identify potential miRNA biomarkers for various hu...
Citation: BMC Systems Biology 2018 12(Suppl 9):121
Signaling pathways are the key biological mechanisms that transduce extracellular signals to affect transcription factor mediated gene regulation within cells. A number of computational methods have been devel...
Citation: BMC Systems Biology 2018 12(Suppl 9):120
Citation Impact
2.05 - 2-year Impact Factor
2.505 - 5-year Impact Factor
0.689 - Source Normalized Impact per Paper (SNIP)
1.109 - SCImago Journal Rank (SJR)
Usage
852,052 downloads
Social Media Impact
523 mentions