Table 3 Estimated concentrations (in μM) of the iron-containing components of the C9 model. For each entry, the top number is data-based while the bottom number is the corresponding simulated value. The sum of these concentrations, after multiplying each by their respective fractional volume, approximately equals [Fecell]. The sum of the concentrations of each species located in each compartment (cyt, mitochondria, and vacuoles) approximately equals [Fecyt], [Femit], and [Fevac], respectively
From: A mathematical model of iron import and trafficking in wild-type and Mrs3/4ΔΔ yeast cells
[N] | [C] | [CIA] | [FM] | [FS] | [MP] | [F2] | [F3] | [VP] |
|---|---|---|---|---|---|---|---|---|
WT | ||||||||
1 | 2.5 | 92 | 60 | 320 | 0 | 60 | 0 | 0 |
1.5 | 16 | 110 | 160 | 90 | 14 | 85 | 0 | |
2 | 3 | 84 | 80 | 290 | 60 | 96 | 780 | 0 |
2.7 | 79 | 190 | 380 | 62 | 43 | 590 | 2.6 | |
11 | 4 | 250 | 140 | 380 | 30 | 320 | 1900 | 0 |
5.6 | 210 | 430 | 730 | 71 | 250 | 540 | 320 | |
41 | 5 | 380 | 210 | 480 | 0 | 450 | 4600 | 0 |
6.0 | 220 | 470 | 750 | 75 | 290 | 5200 | 440 | |
ΔΔ | ||||||||
1 | 3 | 130 | 60 | 40 | 530 | 140 | 400 | 0 |
2.6 | 310 | 3.6 | 0.8 | 580 | 2300 | 57 | 0.6 | |
2 | 4 | 160 | 60 | 40 | 530 | 1300 | 3400 | 170 |
4.3 | 470 | 100 | 350 | 140 | 180 | 4600 | 2000 | |
11 | 8 | 340 | 85 | 300 | 300 | 950 | 11,000 | 6400 |
8.6 | 340 | 150 | 330 | 70 | 1200 | 11.000 | 7500 | |
41 | 10 | 280 | 110 | 560 | 80 | 1000 | 22,000 | 13,000 |
9.2 | 280 | 140 | 260 | 71 | 1600 | 10,000 | 5700 | |