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Fig. 8 | BMC Systems Biology

Fig. 8

From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Fig. 8

Model prediction of the implications of HSC activation in chronic ethanol-fed rats. a Chronic ethanol use leads to increased levels of pro-inflammatory and anti-inflammatory cytokines following PHx. b Chronic ethanol appears to lead to a deficient pro-regenerative HSC response following PHx. c The effects of increased cytokine production, imbalanced HSC functional states, and changes to the tissue microenvironment combine to suppress regeneration following ethanol adaptation. The simulated regeneration profile of ethanol adapted rats is consistent with results from [38]. d-f Hepatocyte response to ethanol feeding and PHx. (G-I) Selected tissue microenvironment responses to ethanol feeding and PHx

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BMC Systems Biology

ISSN: 1752-0509

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