Fig. 7From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamicsModel analysis shows the impact of imbalances among multiple hepatic stellate cell transcriptional states on liver regeneration dynamics (a-b) Topographic map representation of HSC states shows the clustering of HSCs in each condition measured. c HSC behavior is constrained prior to 24Â h post-PHx even after increasing the baseline fraction of pro-regenerative HSCs. This behavior assumes the absence of other changes associated with changing baseline amounts. d Similar to the phase plane behavior, transition dynamics converge prior to 24Â h post-PHx. e Increasing the baseline amount of pro-regenerative HSCs has little effect on the dynamic regeneration profile. f HSC behavior is constrained prior to 24Â h post-PHx even after increasing the baseline fraction of anti-regenerative HSCs. This behavior assumes the absence of other changes associated with changing baseline amounts. g Similar to the phase plane behavior, transition dynamics converge prior to 24Â h post-PHx. h Increasing the baseline amount of anti-regenerative HSCs has little effect on the dynamic regeneration profile. i Increasing the quiescent to anti-regenerative transition rate leads to a dynamic change in HSC transcriptional state balances. j HSC transition dynamics change based on the balance of transition rates. k Increasing the quiescent to anti-regenerative transition rate causes a suppressed regeneration profile. This type of profile may be representative of liver function in diseased states, such as liver fibrosisBack to article page