Fig. 7

Flux-based model reduction alters system dynamics of metabolic components. Simulated dynamics of E. coli metabolism obtained in the absence of model reduction of the E. coli core genomic model (blue line), with a pruned model (red line) and with a pruned and compressed system (green line). Time-series for G3P, G6P and DHAP are shown. Models were simulated for 400 s with a G3P pulse after 200 s