Fig. 3

Obtained prior and posterior distributions for parameters in the E. coli iJO1366 genome scale model. Examples of distributions obtained for median a & d k^M, b & e k^cat and c & f k^eq values in the E. coli iJO1366 genome scale model from the PB method and from parameter optimisation routines in published models. a — c The blue distributions are prior distributions obtained from databases, the red distributions are the pseudo values used when there is no prior information, and the green distributions are posterior distributions obtained after balancing. d — f The green distributions are the posterior distributions shown in (a — c). The yellow distributions are taken from [55]. The pink distributions are taken from [56]. Only parameters with prior information resulting from the parameter search are included in the comparison