Table 4 Synergistic rules
From: In silico drug combination discovery for personalized cancer therapy
Rule | Positive | Negative | p-value | Reference |
|---|---|---|---|---|
| Â | synergy score | synergy score | Â | Â |
Target: mTOR, DNA GEX: underexpressed HES5 | 23.055 | 8.651 | 1.3e−10 | |
Target: EGFR, mTOR, PI3K GEX: underexpressed SNW1 | 22.219 | 8.588 | 6e−5 |  |
Target: mTOR, PI3K, DNA GEX: underexpressed MAPK14, underexpressed NOTCH4 | 19.8 | 6.231 | 5e−7 |  |
Target: SRC, TOP1 GEX: underexpressed TGFBR2, underexpressed ERBB3 | 28.089 | 7.113 | 2e−5 |  |