Fig. 6
From: Construction and analysis of gene-gene dynamics influence networks based on a Boolean model
Out-degree and in-degree comparisons between non-drug targets and drug-targets in GDI network derived from HSN. a Result of out-degree. The average out-degree of the drug-targets with side-effects was larger than those of non-drug targets and drug-targets without side-effects in every mutation duration time except for T = 2 (All P-values <0.0001). b Result of in-degree. Non-drug target, drug-target without side-effect, and drug-target with side-effect are represented by blue, red, and green color, respectively. The average in-degree of the drug-targets with side-effects was smaller than those of non-drug targets and drug-targets without side-effects in every mutation duration time (All P-values <0.0001). The mutation duration time was varied from 2 to 20