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Fig. 8 | BMC Systems Biology

Fig. 8

From: Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

Fig. 8

Effect of the diffusion coefficient on target gene mRNA expression. a: The value of the diffusion coefficient is varied over several orders of magnitude and the relative change of target gene mRNA expression in the readout cell is calculated. b: The influence of the diffusion coefficient on magnitude and spatial range of target gene expression is exemplarily shown for different diffusion coefficients, as indicated in (a): (i) D=0.15 \(\frac {\mu m^{2}}{s}\), (ii) D=1 \(\frac {\mu m^{2}}{s}\), (iii) D=10 \(\frac {\mu m^{2}}{s}\) (reference parameter set), (iv) D=500 \(\frac {\mu m^{2}}{s}\)

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