Parameter | Description | Value |
---|---|---|
\(D_{A_{O}}\) | Diffusion coefficient of A βO | 4.32×10−2 c m 2 day −1 estimated |
D H | Diffusion coefficient of HMGB-1 | 8.11×10−2 c m 2 day −1 estimated |
\(D_{T_{\alpha }}\) | Diffusion coefficient for TNF- α | 6.55×10−2 c m 2 day −1 estimated |
\(d_{T_{\beta }}\) | Diffusion coefficient of TGF- β | 6.55×10−2 c m 2 day −1 estimated |
\(D_{I_{10}}\) | Diffusion coefficient of IL-10 | 6.04×10−2 c m 2 day −1 estimated |
D P | Diffusion coefficient of MCP-1 | 1.2×10−1 c m 2 day −1 estimated |
\(\lambda _{\beta }^{i} \) | Production rate of \(A_{\beta }^{i}\) | 9.51×10−6 g/ml/day estimated |
λ N | Production rate of \(A_{\beta }^{o}\) by neuron | 8×10−9 g/ml/day estimated |
λ A | Production rate of \(A_{\beta }^{o}\) by astrocytes | 8×10−10 g/ml/day estimated |
λ τ0 | Production rate of tau proteins in health | 8.1×10−11 g/ml/day estimated |
λ τ | Production rate of tau proteins by ROS | 1.35×10−11 g/ml estimated |
λ F | Production rate of NFT by tau | 1.662×10−3/day estimated |
\(\lambda _{AT_{\alpha }}\) | Production/activation rate of astrocytes by TNF- α | 1.54/day estimated |
\(\lambda _{AA_{\beta }^{o}}\) | Production/activation rate of astrocytes by \(A_{\beta }^{o}\) | 1.793/day estimated |
\(\lambda _{A_{O}}\) | Production rate of A βO | 5×10−2/day estimated |
λ H | Production rate of HMGB-1 | 3×10−5/day estimated |
λ MF | Production/activation rate of microglias by NFT | 2×10−2/day estimated |
λ MA | Production/activation rate of microglias by astrocytes | 2.3×10−3/day estimated |
\(\lambda _{M1T_{\beta }}\) | Rate of M 1→M 2 | 6×10−3/day estimated |
\(\lambda _{\hat {M}_{1}T_{\beta }}\) | Rate of \(\hat {M}_{1}\rightarrow \hat {M}_{2}\) | 6×10−4/day estimated |
\(\lambda _{T_{\beta } M}\) | Production rate of TGF- β by M | |
\(\lambda _{T_{\beta }\hat {M}}\) | Production rate of TGF- β by \(\hat {M}\) | |
\(\lambda _{T_{\alpha } M1}\) | Production rate of TNF- α by M 1 | 3×10−2 day −1 estimated |
\(\lambda _{T_{\alpha } \hat {M}_{1}}\) | Production rate of TNF- α by \(\hat {M}_{1}\) | 3×10−2 day −1 estimated |
\(\lambda _{I_{10}M_{2}}\) | Production rate of IL-10 by M 2 | |
\(\lambda _{I_{10}\hat {M}_{2}}\) | Production rate of IL-10 by \(\hat {M}_{2}\) | |
λ PA | Production rate of MCP-1 by astrocytes | 6.6×10−8 day −1 estimated |
\(\lambda _{PM_{2}}\) | Production rate of MCP-1 by M 2 | 1.32×10−7 day −1 estimated |
θ | M 2/M 1 effectivity in clearance of \(A_{\beta }^{o}\) | 0.9 estimated |
α | Flux rate of macrophages | 5 estimated |
β | Proinflammatory/anti-inflammatory ratio | 10 estimated |
γ | I 10 inhibition ratio | 1 estimated |