Fig. 4

Distribution of coherent/incoherent edge pairs. The red/grey/blue bars of the histogram represent counts of the coherent and incoherent actions of the drug pairs on common targets. The histogram is significantly skewed, meaning that many drug pairs tend to have an abundance of coherent actions or of incoherent actions, rather than of both simultaneously. When the overabundance is statistically significant (binomial cumulative distribution test, p-value of 0.05, see Methods), then the bars are coloured: red for overabundance of coherent actions, blue for incoherent actions. The green bars overlaying to the other bars represent the distribution of the coherent/incoherent actions for the null model. For nearly all drug pairs, nonzero green bars reach at most 4 targets in common, counting together coherent and incoherent actions, i.e., the two tails are absent in a null model