Fig. 7

Model-selection implication for G0 re-entry of HSCs in leukemic BM. a Failure of the plain model, which is not encoding G0 re-entry, for representing the kinetics of quiescent HSCs. b Success of the model including the G0 re-entry for representing the kinetics of quiescent HSCs. Here we show one specific example in which the G0 re-entry is formulated by the most common first-order kinetics, ie linear form. See also Additional file 5: Figure S5 for supplemental results where the G0 re-entry adopts other forms. c Box plot illustrating that the fitness of the model with G0 re-entry is higher than the plain model (one-tail t-test, ^* p < 0.1). See also Additional file 5: Figure S5 for supplemental results in which models with (other forms of) G0 re-entries uniformly have higher fitness degrees than the plain model. d GSEA for BM HSCs from day 14 leukemia and control mice. The up-regulation or down-regulation of quiescence-associated gene expressions (left panel) and proliferation-associated gene expressions (right panel) are shown. The normalized enrichment scores (NES) and p-values are indicated in each plot [11]. e The histograms show cell cycle-related gene expressions in BM HSCs at leukemia day 14 compared to control. CKIs (left panel), CDKs (middle panel) and cyclins (right panel) were shown. Data are represented as the mean ± SEM (n = 3, 3 independent experiments), ^* p < 0.05, ^** p < 0.01 [11]