Fig. 7

Dose-response curves for enzymatic SAMPs with different allosteric properties. For coherent proteins depicted in red (blue) enzymatic and binding cooperativity are both positive (negative). The purple proteins are incoherent modulators, in which the two allosteric effects oppose each other. a α _E  = 10 α _B  = 0.1 b α _E  = 10 α _B  = 10 c α _E  = 0.1 α _B  = 10 d α _E  = 0.1 α _B  = 0.1. The different curves result from variations in the total modulator concentration [M_T] = (0.5, 1.5, 3, 7, 10, 20) μM in each case. Red (blue) lines denote antagonistic (inverse antagonistic) responses. The color intensity of each line correlates with the magnitude of the output dynamic range in each case. Other parameters: [R_T] =10 μM, κ = γ = k₋₁ = k₂ = k₋₃ = k₋₄ = k₋₅ = 1 s⁻¹ and k₁ = k₃ = 1 s⁻¹ μM⁻¹. k₄, k₅, k₆ are determined by the allosteric parameters and the requirement for detailed balance