Low potency toxins reveal dense interaction networks in metabolism

Bains, William

doi:10.1186/s12918-016-0262-7

BMC Systems Biology

Table 3 Biological datasets

From: Low potency toxins reveal dense interaction networks in metabolism

Data set	Number of compounds	Species	Measured endpoint	Source
Whole organism toxicity endpoints
Trout (24 h)	186	Oncorhynchus mykiss	Death	[111]	These two data sets differ only in the time of exposure – 1 and 3 days
Trout (96 h)	181	Oncorhynchus mykiss	Death	[111]
Pteronarcys (24 h)	52	Pteronarcys californica	Death	[111]	These two data sets differ only in the time of exposure – 1 and 3 days
Pteronarcys (96 h)	52	Pteronarcys californica	Death	[111]
Bluegill (24 h)	157	Lepomis macrochirus	Death	[111]	These two data sets differ only in the time of exposure – 1 and 3 days
Bluegill (96 h)	172	Lepomis macrochirus	Death	[111]
Gammarus (24 h)	113	Combined data from G. fasciatus, G. lacustris and G. Pseudolimnaeus	Death	[111]	These two data sets differ only in the time of exposure – 1 and 3 days
Gammarus (96 h)	132		Death	[111]
Fathead minnow	578	Pimephales promelas	Death	[112]
Rat oral	814	Rattus norvegicus	Death	[113]	Rodent toxicity data was manually curated from The Merck Index. Note that ‘molar’ values for mammalian whole organism studies are calculated as moles/kg body mass
Mouse oral	398	Mus musculus
Rat IP	170	Rattus norvegicus
Mouse IP	290	Mus musculus
AMES (mutagenicity)	163	Salmonella typhimurium	Mutated colony formation	Data collected and provided by Choracle Ltd, derived from Toxnet [114]
CPDBAS rat	519	Rattus norvegicus	Tumour formation frequency	[115]
CPDBAS mouse	402	Mus musculus
CPDBAS hamster	44	Mesocricetus auratus
Drosophila	139	Drosophila melanogaster	Death	[116]	Only compounds with at least two compound concentrations reported included
Lemna - non-Herbicides	149	Lemna gibba and Lemna minor	lack of growth/leaflet reduction	[117–136]	Compounds developed for reasons other than their herbicide effect
Lemna - Herbicides	174	Lemna gibba and Lemna minor	lack of growth/leaflet reduction	[117]	Compounds developed as herbicides (primarily for macroscopic land plants)
Tetrahymena	334	Tetrahymena pyriformis	Death	[137–140]
Chlorella	91	Chlorella vulgaris	Death	[141]
Scenedesmus	63		Cell numbers (combination growth inhibition and death)	[142–154]	Data-set heavy on chlorinated and nitrated aromatic compounds
Yeast	253	Saccharomyces cereviseae	Growth inhibition	[106]	Mostly drug-like molecules: See methods section for details of this analysis
Other endpoints
NCI	768	Homo sapiens	Cell number (cell growth vs. cell killing)	[39]	Cell culture assay, not whole organism. Cytotoxicty data from the NCI anti-HIV compounds screening programme.
HERG	229	Homo sapiens	Ion channel blockade	[7]	Ion channel assay in cloned receptor assay, not whole organism test
Oestrogenic	131	Rattus norvegicus	Receptor binding IC₅₀	[155]	Receptor binding assay, not a cell- or organism-based assay
Tadpole narcosis	141	Rana temporaria	Narcosis (reversible lack of motion)	[29]
COX-2	107	N/A	Cycloxygenase-2 inhibition	[156]
Antihistamine	61	N/A	Histamine receptor blockade	[157–159]	A variety of related structures, including anti-psychotics

Data sets used in this paper

Back to article page

ISSN: 1752-0509

Contact us

General enquiries: ORSupport@springernature.com