Table 5 Rate laws and their reaction categories. This table gives an overview of all rate laws that are currently implemented in the software SBMLsqueeezer 2. All rate laws are described in detail in [67, p. 17–38]. The key idea of the algorithm in this paper is to separate the list of available rate laws from more general reaction categories to which these rate laws can be applied. With this separation, extending this list and to add more specific rate laws becomes very straightforward to do as long as each such rate law specifies to which categories it can be assigned. Table 4 provides a detailed overview of all categories. Example reactions for all categories can be seen in Fig. 2. The rate laws mentioned in this table are again families of equations. The precise structure of the equation that is generated for a specific reaction can vary, depending on several reaction properties, e.g., how many and which kind of modifiers participate in this reaction, if it is reversible, etc. The creation of the specific equation including its parameters and required units is therefore the next step of the algorithm

From: SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks