Figure 4

Network visualization of a subnetwork underlying the signature for module B. Network visualization of the subnetwork with highest relevance scores for linking intervention targets and module B for DLI (A) and T0901317 (B). The subnetwork was obtained by including edges with relevance score above a dynamically obtained cutoff, which is 0.024 for DLI and 0.021 for T0901317, and all edges that connect nodes within module B (pink edges). Nodes with a red border are part of the co-expression module B. Node size and edge weight are scaled by relevance scores as calculated by the kWalks algorithm. Nodes are colored by log2 ratio of intervention versus high-fat diet gene expression and their shape indicates level of significance of differential expression (p < 0.05 has a round shape, FDR adjusted p < 0.05 has an octagon shape).