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Figure 8 | BMC Systems Biology

Figure 8

From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data

Figure 8

Development Hedgehog Signaling which is the top scored pathway map in MetaCore enrichment analysis results. The family of protein called Hedgehog controls and patterns various aspects of the vertebrate body plan such as survival, cell growth and etc. Ubiquitin was down-regulated while Cullin 3 and Cul3/SPOP/Rbx 1 E3 ligase complex was up-regulated in stoke samples at 3, 5, 24 hours and overall stroke samples as compared with control. ITCH was up-regulated in overall stroke samples. Figure 8-12: *Experimental data from all files is linked to and visualized on the maps as thermometer-like figures. Up-ward thermometers have red color and indicate up-regulated signals and down-ward (blue) ones indicate down-regulated expression levels of the genes. [The above paragraph is directly cited from the Metacore results.]

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BMC Systems Biology

ISSN: 1752-0509

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