Table 5 Potential SCZ drugs identified by using different data sources and threshold
From: A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case
Data source | Threshold | #Potential SCZ drugs | #Drugs in SCZ-CTa | #Drugs in MTL-CTb |
|---|---|---|---|---|
WinDTome | Score_S ≥ 3 | 264 | 39 (14.8%) | 74 (28.0%) |
|  | Score_S ≥ 2 | 1,354 | 76 (5.6%) | 102 (7.5%) |
|  | Score_S ≥ 1 | 37,680 | 191 (0.5%) | 292 (0.8%) |
DrugBank | Â | 490 | 45 (9.2%) | 87 (17.8%) |
KEGG | Â | 375 | 30 (8.0%) | 70 (18.7%) |
TTD | Â | 2,388 | 27 (1.1%) | 62 (2.6%) |
MATADOR | Â | 374 | 48 (12.8%) | 82 (21.9%) |
PDSP | Â | 2,001 | 39 (1.9%) | 59 (2.9%) |
BindingDB | Â | 34,748 | 41 (0.1%) | 98 (0.3%) |
STITCH | Combined score ≥ 0.7 | 32,282 | 100 (0.3%) | 241 (0.7%) |