Figure 1

Correlation analysis. A) Distribution of Pearson correlation coefficients - normalized to unit area - for all combinations of miRNA and mRNA expression profiles in normal and cancer tissues (black and red lines, respectively). B) Schematic representation of pairs-selection criteria: among all possible miRNA/mRNA pairs, we selected only those involving mRNAs that were highly correlated with (at least) one lncRNA in the normal dataset. C) Distributions of Pearson correlation coefficients - normalized to unit area - of miRNA/mRNA pairs, selected as described in panel B. The various distributions are plotted as a function of different correlation threshold values, as indicated in the inset, for normal (left side) and cancer dataset (right side).