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Table 5 Promoters for the OI-MET gene set, proportion with TF motifs tested singly and compared to all promoters

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

 

AP1

MAFF

ATF3

MYC

IRF6

NFKB1

OVOL

STAT

MYB

Motif name

V$AP1F

V$AP1R

V$CREB

V$EBOX

V$IRFF

V$NFKB

V$OVOL

V$STAT

V$MYBL

# sequences with motif

1380

3193

3267

2472

2696

2386

1467

3191

2873

p- value

5.9E-01

3.1E- 02

7.7E-01

3.8E- 08

1.0E + 00

3.9E- 27

1.0E + 00

9.9E-01

1.0E + 00

Observed proportion

33.6%

77.8%

79.6%

60.3%

65.7%

58.2%

35.8%

77.8%

70.0%

Expected proportion

33.8%

76.6%

80.1%

56.1%

70.5%

49.8%

41.1%

79.4%

74.7%

Fold enrichment

0.995

1.016

0.994

1.074

0.932

1.168

0.870

0.980

0.938

  1. When tested singly, only MAFF, MYC, and NFKB motifs are enriched in promoters from the OI-MET gene set.
  2. Values in bold are significant at the p-value < 0.05 level.