Table 1 Summary of the pathways considered together with the objectives used for each example
From: Global dynamic optimization approach to predict activation in metabolic pathways
Label | Short description | Problem formulation | ||
|---|---|---|---|---|
Single-objective | Ref. | Multi-objective | ||
LPN3B | Linear pathway with three enzymatic reactions | Min. final time | [7] | Min. final time and intermediate consumption |
LPDN4 | Linear pathway with four enzymatic reactions | Min. final time plus enzyme consumption | [6] | Min. final time and enzyme consumption |
GDB | Branched pathway with four enzymatic reactions | Min. final time | [15] | a) Min. final time and enzyme consumption |
b) Max. concentration of pathway products | ||||
S C | Simplified model of the central metabolism of Saccharomyces cerevisiae | Max. survival time | Max. survival time and min. enzyme cost | |