Figure 5

Type I IFN pathway model simulations during the first 8 hours after IFN-beta stimulation. (A) Model simulations showing oscillations of total (nuclear plus cytoplasmic) pSTAT1 protein, SOCS1 mRNA expression (dashed line) and STAT1 mRNA expression (dotted line). (B) Corresponding simulations where the SOCS1-mediated negative feedback is disrupted by assuming an infinite value of the repression threshold k _I . (C) Corresponding simulations not including the IRF1-mediated positive feedback, by assuming a zero value of the STAT1 activation threshold k _F (which leads to saturation of the corresponding Hill function, so that the dependence of a expression on F is removed).