Figure 4

Workflow for development of draft models: These models are developed from a sequenced genome and curated genome scale model of related organism. The right hand side outlines the steps required to evaluate the reactions in i Cyt773 for their presence in the other organisms. The steps to retrieve gene annotations and resolve any conflicts are shown on the left hand side. The steps in gray were automated, whereas the manually performed step, the resolution of conflicting annotations, is shown in white.