Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

BMC Systems Biology

Table 3 Parameter ranges and mean values for the observations in the six N-way HC-PLSR clusters

Cluster	v_mB(nMh^-1)	v_mC(nMh^-1)	v_mP(nMh^-1)	v_dPCN(nMh^-1)	v_dIN(nMh^-1)	k₁(h^-1)	k₃(nM^-1 h^-1)	k₅(h^-1)	k₇(nM^-1 h^-1)
1	0.02-0.23 (0.11)	0.95-1.12 (0.99)	1.14-2.09 (1.65)	0.99-1.14 (1.06)	0.08-1.52 (0.81)	0.08-1.52 (0.78)	0.08-1.52 (0.82)	0.27-0.41 (0.34)	0.05-0.95 (0.49)
2	0.02-0.28 (0.11)	0.95-1.54 (1.26)	0.98-1.14 (1.02)	0.99-1.14 (1.06)	0.08-1.52 (0.77)	0.08-1.52 (0.78)	0.08-1.52 (0.83)	0.27-0.41 (0.34)	0.05-0.95 (0.49)
3	0.02-0.07 (0.04)	1.03-1.54 (1.32)	1.14-2.09 (1.65)	0.99-1.14 (1.07)	0.08-1.52 (0.80)	0.08-1.52 (0.81)	0.08-1.52 (0.77)	0.27-0.41 (0.32)	0.05-0.95 (0.51)
4	0.07-0.33 (0.18)	0.95-1.54 (1.25)	1.14-2.09 (1.70)	0.99-1.14 (1.07)	0.08-1.52 (0.80)	0.08-1.52 (0.79)	0.08-1.52 (0.81)	0.27-0.41 (0.34)	0.05-0.95 (0.50)
5	0.12-0.38 (0.27)	0.95-1.54 (1.29)	0.98-1.30 (1.09)	0.99-1.14 (1.06)	0.08-1.52 (0.80)	0.08-1.52 (0.82)	0.08-1.52 (0.79)	0.27-0.41 (0.34)	0.05-0.95 (0.50)
6	0.23-0.38 (0.33)	0.95-1.54 (1.29)	1.14-2.09 (1.69)	0.99-1.14 (1.07)	0.08-1.52 (0.80)	0.08-1.52 (0.80)	0.08-1.52 (0.79)	0.27-0.41 (0.35)	0.05-0.95 (0.51)

The mean values are given in parenthesis, while the ranges give the minimum and maximum parameter values observed in each cluster.

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