Table 2 Description of the mammalian circadian clock model state variables
State variable name | Unit | Description |
|---|---|---|
M P | nM | Concentration of Per mRNA |
B N | nM | Concentration of non-phosphorylated Bmal1 protein in the nucleus |
M C | nM | Concentration of Cry mRNA |
M B | nM | Concentration of Bmal1 mRNA |
P C | nM | Concentration of non-phosphorylated Per protein in the cytosol |
P CP | nM | Concentration of phosphorylated Per protein in the cytosol |
PC C | nM | Concentration of non-phosphorylated Per-Cry protein complex in the cytosol |
C C | nM | Concentration of non-phosphorylated Cry protein in the cytosol |
C CP | nM | Concentration of phosphorylated Cry protein in the cytosol |
PC CP | nM | Concentration of phosphorylated Per-Cry protein complex in the cytosol |
PC N | nM | Concentration of non-phosphorylated Per-Cry protein complex in the nucleus |
PC NP | nM | Concentration of phosphorylated Per-Cry protein complex in the nucleus |
I N | nM | Concentration of inactive complex between Per-Cry and Clock-Bmal1 in the nucleus |
B C | nM | Concentration of non-phosphorylated Bmal1 protein in the cytosol |
B CP | nM | Concentration of phosphorylated Bmal1 protein in the cytosol |
B NP | nM | Concentration of phosphorylated Bmal1 protein in the nucleus |