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Table 1 Summary of the genes and their functional categories

From: Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease

Biological function   Genesa
Prp(Sc replication and accumulation   A2M, ABCA1, ADAMTS1, APOD, PTGS1, SERPING1
Immune response   
  Complement activation: complement system C3
  Complement activation: coagulation & kallikrein system PDPN, PROS1
  Pattern recognition and other receptor CD14, CD68, ITGB2, FCGR2B, TREM2, TLR2
  Microglia/astrocyte activation related GFAP, PTPN6, STAT1, STAT3, THBS2, TNFRSF1A, VIM
  Cytokine, chemokine and growth factor related CSF1, CSF1R, CXCL10, CX3CR 1
  Leukocyte extravasation CYBB, ITGAX, NCF1, TGFB1, TGFBR1, TGFBR2
  Other immune response AIF1, B2M, CD83, CD86, CEBPA, CEBPD, Ctla2a, HLA-E, IFI27, IFIT3, NFATC1, SBNO2
Cell death   CASP1, CCN D1, CLU, HSPB1, HSPB8, ID3, MCL1, RBP1, SOCS3, TGM2
Other   ALOX5AP, CD9, FLI1, GUSB, HPGD, IL13RA1, INPP5D, ISG15, LCN2, LGAL53, LXN, MET, OSMR, P2RX7, S100A4, SOX9, SRGN, SYNPO, TF
  1. aGenes in the SCC are indicated in bold.