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Table 1 The signals are more biologically meaningful than the noises

From: Identifying biologically interpretable transcription factor knockout targets by jointly analyzing the transcription factor knockout microarray and the ChIP-chip data

Test (with FDR = 0.05)

Test results

Functional enrichment

Our result has an equal or higher enrichment score than the noises in 94% (105/112) of the cases.

Expression coherence

Of the 112 TFs, 57% (64/112) show significantly higher expression coherence in the signals, compared with only 6% (7/112) in the noises.

The prevalence of protein-protein interactions

Of the 112 TFs, 82% (92/112) are enriched for membership to a protein-protein interaction module in the signals, compared with only 19% (21/112) in the noises

  1. To show that the signals are more biologically meaningful than the noises, we assessed the functional enrichment, the expression coherence, and the prevalence of protein-protein interactions. The signals outperform the noises across all measures.
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BMC Systems Biology

ISSN: 1752-0509

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