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Table 2 Identification of HRE motifs for HIF orthologous target genes

From: Functional pathway mapping analysis for hypoxia-inducible factors

Model Species HIF orthologous target genes (KEGG: Orthology K05448)
HSA ENSG00000119630
GGCAGGCGTG CAGACTCA
Loc:-963~-946
TGTGTCCGTG CCTGGCTA
Loc:-1392~-1375
GCCCCTCGTG GGTGGGCA
Loc:-628~-611
ENSG00000112715
TGAGGACGTG TGTGTCTG
Loc:-517~-500
TGCATACGTG GGCTCCAA
Loc:-982~-965
TGTGTGCGTG TGGGGTTG
Loc:-485~-468
ENSG00000173511
CGAGATCGTG CCCCGGGG
Loc:-641~-624
GGAGCGCGTG TCTGGGTC
Loc:-277~-260
CTCACGCGTG CCACGGAG
Loc:-1601~-1584
MMU ENSMUSG00000004791
TGAGCACGTG TGGATCCT
Loc:-542~-525
CCAATCCGTG TGTGCTCA
Loc:-204~-187
ATGTCACGTG AAATGACG
Loc:-122~-105
ENSMUSG00000023951
TGCATACGTG GGTTTCCA
Loc:-1082~-1065
AGTCTGCGTG AGGGAGGA
Loc:-1538~-1521
TGAGTGCGTG CATGCATG
Loc:-1570~-1553
ENSMUSG00000024962
TCCCCTCGTG AGGCAGCG
Loc:-1799~-1782
ACTACACGTG CAATAAAC
Loc:-1726~-1709
GTCAAGCGTG CTGAGGCC
Loc:-287~-270
GGA ENSGALG00000010290
CCCCGACGTG CGGAGCGG
Loc:-1970~-1953
TGGCACCGTG CTGGAATA
Loc:-143~-126
CCCCATCGTG CAGCCCCA
Loc:-208~-191
N/A N/A
DRE ENSDARG00000034700
CCTGTACGTG GTGATGGA
Loc:-997~-980
TATCGTCGTG TTGTGATT
Loc:-1106~-1089
TTAAACCGTG TGCGCTGC
Loc:-55~-38
N/A N/A
XTR ENSXETG00000016375
TGTCTCCGTG TAATCGCG
Loc:-1289~-1272
TAATCGCGTG CTGATAAC
Loc:-1273~-1262
N/A N/A
CIN ENSCING00000014020
CAGATACGTG ATCTTGGT
Loc:--1977~-1960
TTACGACGTG GACATTCC
Loc:-1475~-1458
CGCCATCGTG CGAAGGCA
Loc:-150~-133
N/A N/A
  1. The locations of HRE motifs were detected within the HIF orthologous genes for 6 model species (the PSSM pattern of V$HIF_STKR_2005 and the core segment “CGTG” pattern were required to exactly match and shown in bold and underline). The regions were identified within 2,000 base pairs upstream of the orthologous gene set of KEGG: Orthology K05448 (VEGFA_B); only the first 3 detected HREs are shown here. The Ensembl gene IDs are shown on the top of each identified HRE motif. Only 2 HRE motifs were found in XTR within the assigned promoter region. HSA, H. sapiens; MMU, M. musculus; GGA, G. gallus; DRE, D. rerio; XTR, X. tropicalis; CIN, C. intestinalis