Figure 10

PONDR^® prediction and experimentally solved structure of aIF2β from Sulfolobus solfataricus . The PONDR^® VSL2 prediction is given in the plot, where scores greater than 0.5 are predictions of disordered residues and scores less then 0.5 are predictions of ordered residues. Horizontal bars represent regions with known structure, or are likely to be structured, which are (from N- to C- termini): the aIF2γ-binding MoRF region (red bar), the core domain (cyan bar), and the C-terminal zinc finger domain (green bar). Additionally, structures of the aIF2γ-binding MoRF region (red ribbon) bound to aIF2γ (blue surface) and aIF2α (green surface), and of the core domain (cyan ribbon) are shown (coordinates from PDB entries 2QN6 and 2NXU, respectively).