Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Table 4 Transcription factors (TFs) strongly implicated in the regulation of HF core network modules.

TFs	Module	BP	P _TF-Module	KHFB	HTraffic
					ITGB1
					FHL2
E2F-4:DP-2	13	Cell adhesion, signal transduction	0.04	CKM	COL8A1
					CKM
					ITGA2
					ITGB1
					FHL2
E2F-1:DP-2	13	Cell adhesion, signal transduction	0.04	CKM	COL8A1
					CKM
					ITGA2
					ITGB1
					FHL2
E2F-1:DP-1	13	Cell adhesion, signal transduction	0.04	CKM	COL8A1
					CKM
					ITGA2
					ITGB1
			0.04	CKM	FHL2
E2F-1	13	Cell adhesion, signal transduction			COL8A1
					CKM
					ITGA2
					PDGFRB
					ADAM15
E2F-1	16	Cell communication, phosporilation	0.02	IL6	IL6ST
					PDGFRA
					GRB2

BP: Examples of GO biological process over-represented in a module (with P < 0.05 after adjusting for multiple-testing). P_TF-Module: Probability value for the association TF-module (after correcting for multiple-testing). KHFB: Known HF biomarkers controlled by the TF within the specified module. HTraffic: examples of high-traffic proteins, including putative biomarkers, regulated by the specified TF.

ISSN: 1752-0509