Figure 2From: A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorderNetwork Hypothesis. The network developed models the complex gene-by-environment interactions involved in both lithium etiology and comorbid cocaine abuse associated with BD. Consistent with our initial hypothesis, the network is significantly over-represented for genes associated with signal transduction. In addition, the network models related pharmacogenomic, psychiatric, and chemical dependence phenotypes.Back to article page