Enzyme name | Compartment | Pathway | EC | Super-Target | Score |
---|---|---|---|---|---|
adenylate cyclase | apicoplast | Purine metabolism | 4.6.1.1 | x | 4 |
fumarase | cytosol | Citrate cycle | 4.2.1.2 | x | 4 |
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | apicoplast | Biosynthesis of isopentenyl diphosphate | 2.7.7.60 | x | 4 |
4-hydroxy-3-methylbut-2-enoyl-diphosphate synthase | apicoplast | Biosynthesis of isopentenyl diphosphate | 1.17.4.3 | Â | 3 |
CDP-ME kinase | apicoplast | Biosynthesis of isopentenyl diphosphate | 2.7.1.148 | Â | 3 |
pantetheine-phosphate adenylyltransferase | cytosol | CoA biosynthesis | 2.7.7.3 | Â | 3 |
pyridoxal 5-phosphate synthase | cytosol | Vitamin B6 metabolism | Â | Â | 3 |
amino acid transporter | Cytosol ↔ apicoplast | Transport |  |  | 3 |
geranyl-diphosphate synthase | cytosol | Terpenoid biosynthesis | 2.5.1.1 | x | 2 |
farnesyl-diphosphate synthase | cytosol | Terpenoid biosynthesis | 2.5.1.10 | x | 2 |
2-Octaprenylphenol hydroxylase | mitochondrion | Ubiquinone biosynthesis | 1.14.13.- | x | 2 |
ubiquinone biosynthesis methyltransferase | mitochondrion | Ubiquinone biosynthesis | 2.1.1.- | x | 2 |
uroporphyrinogen decarboxylase | apicoplast | Porphyrin metabolism | 4.1.1.37 | x | 2 |
coproporphyrinogen oxidase | apicoplast | Porphyrin metabolism | 1.3.3.3 | x | 2 |
UMP-CMP kinase | apicoplast | Pyrimidine metabolism | 2.7.4.14 | x | 2 |
aspartate carbamoyltransferase | cytosol | Pyrimidine metabolism | 2.1.3.2 | x | 2 |
orotate phosphoribosyltransferase | cytosol | Pyrimidine metabolism | 2.4.2.10 | x | 2 |
cysteine desulfurase | apicoplast/mitochondrion | Fe-S-protein biogenesis | 2.8.1.7 | x | 2 |
tRNA ligase (Ile, Lys, Met, Trp, Tyr) | cytosol/apicoplast/mitochondrion | Aminoacyl-tRNA biosynthesis | 6.1.1.1/6.1.1.2/6.1.1.5/6.1.1.6/6.1.1.10 | x | 2 |
glutathione synthase | cytosol | Glutathione metabolism | 6.3.2.3 | x | 2 |
riboflavin kinase | cytosol | Riboflavin metabolism | 2.7.1.26 | x | 2 |
glucosamine 6-phosphate synthase | apicoplast | Aminosugars metabolism | 2.6.1.16 | x | 2 |
mannose-6-phosphate isomerase | cytosol | Fructose and mannose metabolism | 5.3.1.8 | x | 2 |
cytochrome-c oxidase | mitochondrion | Oxidative phosphorylation | 1.9.3.1 | x | 2 |
choline-phosphate cytidylyltransferase | cytosol | Glycerophospholipid metabolism | 2.7.7.15 | x | 2 |
deoxyhypusine synthase | cytosol | Activation of eiF5A | 2.5.1.46 | x | 2 |