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Table 1 Parameters values, scatter intervals and best fits.

From: Systems analysis of iron metabolism: the network of iron pools and fluxes

  

Fe Deficient

  

Fe Adequate

  

Fe Loaded

 

Parameter

Best Fit

Lower Limit

Upper Limit

Best Fit

Lower Limit

Upper Limit

Best Fit

Lower Limit

Upper Limit

1kp_bon

13.22

12.47

13.63

12.67

12.01

13.26

6.92

6.01

7.09

2kp_kid

0.42

0.28

0.54

0.45

0.36

0.51

1.62

1.18

1.82

3kp_int

0.98

0.77

1.06

0.9

0.63

1.1

0.93

0.66

1.01

4kp_liv

2.27

1.83

2.54

2.61

2.28

2.9

5.25

4.25

5.73

5kp_sto

0.09

0.06

0.18

0.12

0.08

0.17

0.27

0.21

0.37

6kp_intg

1.04

0.89

1.32

1.14

0.96

1.35

1.33

1.05

1.5

7kp_fat

0.04

0.03

0.05

0.05

0.04

0.05

0.066

0.051

0.075

8kp_mus

0.96

0.8

1.23

1.49

1.31

1.8

2.52

2.06

2.75

9kp_lun

0.79

0.64

1.06

0.31

0.22

0.44

0.63

0.56

0.75

10kp_duo

0.02

0.01

0.15

0.04

0.03

0.06

0.038

0.027

0.05

11kp_bra

0.03

0.03

0.03

0.03

0.03

0.04

0.021

0.019

0.022

12kp_hea

0.11

0.1

0.14

0.13

0.12

0.15

0.36

0.31

0.38

13kp_tes

0.04

0.04

0.05

0.06

0.05

0.06

0.043

0.037

2.68

14kkid_p

0.2

0.11

0.32

0.2

0.14

0.25

0.23

0.16

0.32

15kliv_p

0.25

0.21

0.32

0.14

0.11

0.16

0.1

0.073

0.12

16ksto_out

0.18

0.09

1.72

0.37

0.27

0.49

0.29

0.2

0.4

17kfat_p

0.1

0.06

0.19

0.13

0.1

0.15

0.099

0.079

0.12

18kmus_p

0.03

0.02

0.05

0.15

0.12

0.21

0.14

0.11

0.17

19klun_p

0.41

0.37

0.52

0.19

0.11

0.3

0.086

0.065

0.12

20kbra_p

0.02

0.02

0.03

0.06

0.05

0.07

0.028

0.022

0.034

21khea_p

0.06

0.03

0.08

0.08

0.06

0.09

0.17

0.14

0.19

22ktes_p

0.05

0.03

0.07

0.09

0.07

0.12

0.067

0.044

7.16

23kspl_p

14.61

13.86

15

7.29

5.53

9.15

1.91

1.52

2.33

24kintg_out

0.03

0.02

0.05

0.04

0.03

0.06

0.072

0.057

0.102

25kint_out

0.3

0.22

0.4

0.36

0.26

0.42

0.22

0.16

0.26

26kduo_p

0.17

0.12

2.55

0.42

0.32

0.55

0.24

0.18

0.34

27kbon_rbc

1.85

1.74

1.92

1.07

0.93

1.26

0.5

0.48

0.57

28kbon_spl

0.56

0.4

0.83

0.1

0.08

0.13

0.046

0.033

0.058

29krbc_spl

0.03

0.02

0.04

0.06

0.05

0.07

0.032

0.027

0.047

fval chi_sqr (fit criterion)

0.58

  

0.72

  

1.05

  

sq root of mean weighted squared dev (fit quality)

0.07

  

0.08

  

0.07

  
  1. The parameter estimates (expressed per day) were obtained by an optimization algorithm that minimized the fit criterion as defined in the paragraph "parameter estimation strategy" of methods section. Rate parameters were estimated under the assumption of approximate steady-state fluxes. Displayed are the best-fit values. The statistical limit of acceptable parameter value was obtained by perturbing the tracer measurements at random (equidistributed, "Monte-Carlo resampling") around the mean within the standard deviation, both displayed in Additional file 1: Table S1 to S3.
  2. The value of the total plasma iron clearance rate had to be prescribed as fixed value in order to avoid excessive parameter correlation (see paragraph "parameter identifiability"). Their value was chosen to the convenient value of 20 per day, approximately in keeping with the data of Trinder et al. [10] and Brodsky et al.[53]. Any other choice of the total clearance rate will affect all out-of-plasma estimates in the table proportionally.
  3. The criterion of best fit "fval chi_sqr" was selected from an analysis of the data structure (see "fit criterion" in section methods).
  4. "sq root of mean weighted squared dev" (see section "quality of final fit" in methods) is a measure of a typical deviation between measurement and optimal fit.
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BMC Systems Biology

ISSN: 1752-0509

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