Figure 3
From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
Results from the mathematical framework used to study the inhibitory effects of 3-nitropropionate (3-NP). (A) Cell concentration, expressed in units of optical density at 600-nm-wavelength light (OD600), of Mycobacterium tuberculosis in inhibitor-free medium (solid line), in medium with 0.025 mM 3-NP (dashed line), and cell concentrations of the Δicl1 Δicl2 mutant bacterium (dotted line) obtained from our calculation using the described mathematical framework and compared to the corresponding experimental results [46]; (B) The calculated cell concentration, expressed as OD600, of M. tuberculosis is shown as a function of time for different 3-NP inhibitor concentrations and compared to the corresponding experimental data [46]; and (C) The calculated cell concentration, expressed as OD600, of M. tuberculosis after a 16-day growth period as a function of 3-NP inhibitor concentration compared to experimental values [46].