Figure 4

Identification of new target genes for major clusters. (A) The average expression profiles of the four clusters with > 10 members. (B) Expressions of extended regulatory genes sorted by correlation coefficients(c) with the average expression profile of a cluster. Each extended gene group was divided into highly correlated (c > 0.5), un-correlated (t0.5 <c < 0.5) and anti-correlated (c < t0.5) groups. The average gene expression of each cluster is shown as a row at the top of each column. (C) Ratio of highly correlated genes (c > 0.5) in the sets of extended regulatory genes and 1,000 randomly chosen genes. Error bars were calculated as the standard deviation of a population derived from 100 repeated tests. P-values measured by the Fisher's exact test are noted above each column set. (D) Fraction of acceptable new predicted cluster genes from both the extended and "no evidence" gene sets. Significantly expressed genes (p < 0.01) in both sets were plotted against each other using a range of Pearson's coefficient cutoff values for Clusters A, B, D, and G. The dashed line indicates where the fraction of acceptable genes is equal from both the extended and "no evidence" sets