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Figure 3 | BMC Systems Biology

Figure 3

From: Simple molecular networks that respond optimally to time-periodic stimulation

Figure 3

The graph of extremum values of Y in function of σ for a simple activation process. The extremum values of Y in function of σ for a simple activation process (Fig 1. (a)) are plotted thanks to the equations (2) of the main text. Y max is the maximum reached by the protein, <Y > T is the mean concentration of the protein averaged over one period T, Y min is the minimal value reached by the protein, κ = β α MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaeqOUdSMaeyypa0tcfa4aaSaaaeaacqaHYoGyaeaacqaHXoqyaaaaaa@326B@ (dotted line) represents the stationary state that the protein would attain if the stimulation was constant and Y L (dashed line) is the asymptotic value reached by Y max when the inter-pulse interval σ becomes very large. The parameters are: α = 0.01 min-1, β = 10 nM.min-1, τ = 100 min.

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