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Table 2 Evaluation of prediction method variants on human reference and supported subsets

From: Protein-protein interaction as a predictor of subcellular location

PPI sets DISCRETE MERGED COMMON MAJORITY
  PA SA PA
(M)
SA
(M)
PA SA PA
(M)
SA
(M)
PA SA PA
(M)
SA
(M)
PA SA PA
(M)
SA
(M)
Reference 0.64 0.35 0.50 0.27 0.72 0.26 0.62 0.23 0.65 0.40 0.53 0.32 0.68 0.34 0.58 0.27
BPscore 0.84 0.56 0.76 0.46 0.86 0.55 0.79 0.42 0.85 0.57 0.77 0.47 0.86 0.55 0.79 0.43
Interologs 0.85 0.58 0.70 0.46 0.84 0.54 0.69 0.42 0.83 0.57 0.67 0.45 0.84 0.56 0.69 0.45
DDI 0.72 0.46 0.65 0.43 0.75 0.43 0.70 0.42 0.72 0.48 0.66 0.49 0.74 0.45 0.69 0.44
PMID 0.76 0.46 0.60 0.28 0.76 0.42 0.60 0.27 0.74 0.45 0.56 0.30 0.76 0.43 0.59 0.28
Method 0.74 0.38 0.61 0.29 0.76 0.37 0.63 0.27 0.73 0.41 0.58 0.32 0.75 0.38 0.62 0.29
DB 0.73 0.37 0.53 0.25 0.74 0.35 0.61 0.26 0.71 0.40 0.57 0.30 0.73 0.37 0.59 0.28
ALL 0.74 0.42 0.61 0.35 0.78 0.38 0.69 0.33 0.74 0.45 0.64 0.40 0.76 0.41 0.67 0.36
BIO 0.77 0.49 0.67 0.43 0.79 0.45 0.71 0.38 0.77 0.50 0.67 0.45 0.78 0.47 0.70 0.41
EVI 0.74 0.37 0.55 0.25 0.75 0.34 0.62 0.25 0.71 0.41 0.57 0.30 0.74 0.37 0.61 0.27
  1. ALL: Union of all subsets (BPscore Interologs DDI PMID Method DB)
  2. BIO: Union of biological evidence type subsets (BPscore Interologs DDI)
  3. EVI: Union of recorded evidence type subsets (PMID Method DB)
  4. M: Interactions involving an integral membrane protein
  5. The permissive accuracy (PA) and strict accuracy (SA) were calculated for all variants (DISCRETE, MERGED, COMMON and MAJORITY) for all interactions, and for interactions involving an integral membrane protein (M).