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Table 3 The top 50 effect terms of reactions with "pathway step" and "molecular interaction" type in the TRANSPATH database.

From: Systematic reconstruction of TRANSPATH data into Cell System Markup Language

No. Effect Rule #(%) No. Effect Rule #(%)
1 binding 1-1 28411 (29.5%) 26 sumoylation 1-1 89486 (92.8%)
2 expression 5-1 53378 (55.4%) 27 decrease of phosphorylation 3-1 89846 (93.2%)
3 DNA binding 4-1 59299 (61.5%) 28 dephosphorylation 1-1 90183 (93.5%)
4 phosphorylation 1-1 64800 (67.2%) 29 increase of binding 2-1 90516 (93.9%)
5 activation 2-1 68829 (71.4%) 30 predicted 7 90844 (94.2%)
6 increase of abundance 2-1 72516 (75.2%) 31 binding; phosphorylation 1–2 91130 (94.5%)
7 DNA binding; transactivation 4-1 75753 (78.6%) 32 translocation 1-1 91397 (94.8%)
8 decrease of abundance 3-1 77255 (80.1%) 33 acetylation 1-1 91629 (95%)
9 increase of phosphorylation 2-1 78570 (81.5%) 34 binding; oligomerization 1–2 91853 (95.3%)
10 regulation of abundance 6-2 79728 (82.7%) 35 transrepression 2–3 92052 (95.5%)
11 inhibition 3–4 80790 (83.8%) 36 regulation of phosphorylation 2–4 92247 (95.7%)
12 regulation of activity 6-1 81810 (84.9%) 37 decrease of secretion 3-1 92425 (95.9%)
13 regulation of localization 2–4 82806 (85.9%) 38 activation; binding 3-2 92585 (96%)
14 transactivation 2-1 83507 (86.6%) 39 automodification; phosphorylation 1-1 92734 (96.2%)
15 DNA binding; transregulation 4-3 84120 (87.3%) 40 degradation 1-1 92866 (96.3%)
16 increase of secretion 2-1 84721 (87.9%) 41 exchange 1-1 92995 (96.5%)
17 regulation of protein activity 6-1 85280 (88.5%) 42 oligomerization 1-1 93114 (96.6%)
18 DNA binding; transrepression 4-2 85814 (89%) 43 decrease of protein stability 3-3 93226 (96.7%)
19 cleavage 1-1 86327 (89.5%) 44 hydrolysis 1-1 93327 (96.8%)
20 activation; increase of phosphorylation 2-2 86836 (90.1%) 45 dissociation; phosphorylation 1–3 93420 (96.9%)
21 activation; expression 5-2 87309 (90.6%) 46 degradation; destabilization 3-3 93510 (97%)
22 ubiquitination 1-1 87766 (91%) 47 regulation of secretion 6-2 93593 (97.1%)
23 binding; regulation of localization 1–2 88216 (91.5%) 48 activation; increase of abundance 2-2 93673 (97.2%)
24 processing 1-1 88665 (92%) 49 increase of processing 2-1 93753 (97.3%)
25 binding; regulation of protein activity 1–2 89094 (92.4%) 50 decrease of binding 3-1 93832 (97.3%)
  1. These 50 terms are used to annotate the effects of reactions (pathway step and molecular evidence type), and occupy 97.3% of the total number of reactions (96404). The No. column lists the frequency order of the effect terms; the Effect terms; the Rule number in Figure 7; and the #(%) column, the accumulated frequency and its percentage in parentheses.