Figure 4

Yeast gene co-expression module networks: the relationship between fundamental network concepts NetworkConcept ( A - I ) (y-axis) and their approximate CF-based analogs NetworkConcept_CF,app(x-axis). This figure demonstrates Observation 2. A reference line with intercept 0 and slope 1 has been added to each plot. The figures on the left (right) hand side depict network concepts from the weighted (unweighted) network. A) and B) Centralization versus Centralization_CF,app; C) and D) Heterogeneity versus Heterogeneity_CF,app; E) and F) Intramodular clustering coefficients ClusterCoef _i versus ClusterCoef_CF,app. The analogous plots for Density are not presented since the fundamental network concepts and their approximate CF-based analogs are almost identical and the dots fall near the reference line with R² = 1 for both weighted and unweighted networks, and thus are omitted due to limited space. In Figures A), B), C) and D), each dot corresponds to a module since these network concepts summarize an entire network module. In Figure E) and F), each dot corresponds to a node since these network concepts are node specific.