Table 2 The top enriched GO pathways (pathway size <100; enrichment p-value < 0.1) which also significantly correlated with treatment response (|correlation|> 0.7; correlation p-value < 0.01)
GO Pathway | Treatment response correlation | GO-Enrichment Pvalue | M_DEG |
|---|---|---|---|
Heparan sulfate proteoglycan metabolic process | 0.81 | 2.50E-06 | EXTL3, HPSE, NDST1, SULF2 |
Cellular carbohydrate catabolic process | 0.86 | 0.00135 | GK5, MGAM, PYGL |
Positive regulation of CD4-positive, alpha-beta T cell activation | 0.90 | 0.00268 | CD55, CD83 |
Hair follicle development | 0.80 | 0.00273 | HPSE, LAMA5, TGM3 |
Molting cycle process | 0.80 | 0.00273 | HPSE, LAMA5, TGM3 |
Hair cycle process | 0.80 | 0.00273 | HPSE, LAMA5, TGM3 |
Skin epidermis development | 0.80 | 0.00283 | HPSE, LAMA5, TGM3 |
Positive regulation vascular endothelial growth factor production | 0.74 | 0.00317 | HPSE, SULF2 |
Glucan catabolic process | 0.88 | 0.00369 | MGAM, PYGL |
Cellular polysaccharide catabolic process | 0.88 | 0.00397 | MGAM, PYGL |
Regulation of vascular endothelial growth factor production | 0.79 | 0.00425 | HPSE, SULF2 |
Polysaccharide catabolic process | 0.88 | 0.00454 | MGAM, PYGL |
Vascular endothelial growth factor production | 0.76 | 0.00485 | HPSE, SULF2 |
Proteoglycan biosynthetic process | 0.76 | 0.01521 | EXTL3, NDST1 |
Myeloid cell activation involved in immune response | 0.78 | 0.01734 | F2RL1, SBNO2 |
Glycosaminoglycan catabolic process | 0.76 | 0.01789 | HPSE, PGLYRP1 |
Cellular glucan metabolic process | 0.75 | 0.03104 | MGAM, PYGL |
Glucan metabolic process | 0.75 | 0.03104 | MGAM, PYGL |
Glomerular epithelial cell development | 0.88 | 0.03312 | IQGAP1 |
Positive regulation of mitochondrial fission | 0.79 | 0.03312 | PINK1 |
Manganese ion transport | 0.73 | 0.03961 | SLC11A1 |
Regulation of hair follicle development | 0.78 | 0.04284 | HPSE |
Cellular polysaccharide metabolic process | 0.72 | 0.04295 | MGAM, PYGL |
Nucleus localization | 0.76 | 0.07144 | TACC3 |
Glycogen catabolic process | 0.88 | 0.08388 | PYGL |
Peptide cross-linking | 0.74 | 0.09616 | TGM3 |
Cell proliferation in forebrain | 0.85 | 0.09616 | TACC3 |
Regulation of CD4-positive, alpha-beta T cell activation | -0.90 | 0.00485 | CD55, CD83 |
Aminoglycan catabolic process | -0.75 | 0.02074 | HPSE, PGLYRP1 |
Regulation of oxidative phosphorylation | -0.76 | 0.03312 | PINK1 |
Nuclear pore organization | -0.80 | 0.03637 | TMEM33 |
Regulation of natural killer cell differentiation | -0.71 | 0.03961 | PGLYRP1 |
Pore complex assembly | -0.72 | 0.03961 | TMEM33 |
Glycoprotein catabolic process | -0.77 | 0.04284 | HPSE |