Table 6 Gene expressions of the significant genes in the model for input signal case 6. Here A1-A6 denotes SCC1-SCC6
From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus
Node | Case 6 | |||||
|---|---|---|---|---|---|---|
A1 | A2 | A3 | A4 | A5 | A6 | |
Apoptosis | 1 | 1 | 1 | 1 | 0 | 0 |
AKT | 0.49 | 0.49 | 0.63 | 0.55 | 0.65 | 0.56 |
APAF-1 | 1 | 1 | 0 | 1 | 0 | 0 |
ASK1 | 1 | 1 | 0 | 0 | 0 | 0 |
ATF4 | 1 | 0 | 0 | 1 | 0 | 1 |
ATF6 | 0 | 0 | 0 | 0 | 0 | 0 |
BAK | 1 | 1 | 0 | 0 | 0 | 0 |
BAX | 1 | 1 | 0 | 0 | 0 | 0 |
BCL2 | 0 | 0 | 1 | 0 | 1 | 0 |
Caspase-3 | 1 | 1 | 1 | 1 | 0 | 0 |
Caspase-6 | 1 | 1 | 1 | 1 | 0 | 0 |
Caspase-7 | 1 | 1 | 1 | 1 | 0 | 0 |
Caspase-8 | 1 | 1 | 1 | 1 | 0 | 0 |
Caspase-9 | 1 | 1 | 1 | 1 | 0 | 0 |
CHOP | 1 | 0 | 0 | 1 | 0 | 1 |
DIABLO | 1 | 1 | 0 | 1 | 0 | 0 |
EIF2S1 | 1 | 0 | 0 | 1 | 0 | 1 |
FADD | 1 | 1 | 0 | 0 | 0 | 0 |
FASR | 0 | 0 | 0 | 0 | 0 | 0 |
FOXO1 | 0 | 0 | 0 | 0 | 0 | 0 |
G6PC | 0 | 0 | 0 | 0 | 0 | 0 |
GADD34 | 1 | 0 | 0 | 1 | 0 | 1 |
GLUT4 | 0.65 | 0.65 | 0.75 | 0.70 | 0.78 | 0.71 |
GRP78 | 1 | 1 | 0 | 1 | 0 | 1 |
GS | 0.49 | 0.49 | 0.62 | 0.54 | 0.65 | 0.55 |
GSK3 β | 0.50 | 0.50 | 0.38 | 0.45 | 0.36 | 0.45 |
HtrA2 | 1 | 1 | 0 | 1 | 0 | 0 |
IKB α | 0 | 0 | 1 | 1 | 1 | 1 |
IKK β | 1 | 1 | 0 | 0 | 0 | 0 |
INS | 1 | 1 | 1 | 1 | 1 | 1 |
INSR | 1 | 1 | 1 | 1 | 1 | 1 |
IRE1 | 1 | 1 | 0 | 0 | 0 | 0 |
IRS | 0 | 0 | 0.19 | 0.22 | 0.18 | 0.22 |
JAK | 0.49 | 0.49 | 0.49 | 0.49 | 0.49 | 0.50 |
JNK | 1 | 1 | 0 | 0 | 0 | 0 |
NFKB | 1 | 1 | 0 | 0 | 0 | 0 |
PEPCK | 0 | 0 | 0 | 0 | 0 | 0 |
PERK | 0 | 0 | 0 | 0 | 0 | 0 |
PI3K | 0.49 | 0.49 | 0.54 | 0.55 | 0.54 | 0.56 |
RAIDD | 1 | 1 | 0 | 0 | 0 | 0 |
RIPK1 | 1 | 1 | 0 | 0 | 0 | 0 |
S6K | 1 | 1 | 0.62 | 0.55 | 0.62 | 0.56 |
SOCS3 | 0.49 | 0.50 | 0.50 | 0.49 | 0.49 | 0.49 |
STAT3 | 0.49 | 0.49 | 0.49 | 0.49 | 0.49 | 0.50 |
TNFR1 | 1 | 1 | 0 | 0 | 0 | 0 |
TNFR2 | 1 | 1 | 0 | 0 | 0 | 0 |
TRADD | 1 | 1 | 0 | 0 | 0 | 0 |
TRAF2 | 1 | 1 | 0 | 0 | 0 | 0 |
TRB3 | 1 | 0 | 0 | 1 | 0 | 1 |
TSC2 | 0 | 0 | 0.37 | 0.45 | 0.36 | 0.44 |
XBP1 | 1 | 1 | 0 | 0 | 0 | 0 |
XIAP | 0 | 0 | 0 | 0 | 1 | 1 |
mTORC1 | 1 | 1 | 0.63 | 0.55 | 0.63 | 0.57 |
p38 | 1 | 1 | 0 | 0 | 0 | 0 |