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Table 2 Boolean functions for the Boolean model

From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

Node

Boolean function

Node

Boolean function

ER

ER

OS

OS

FasL

FasL

TNF α

TNF α or NFKB

IL-6

IL-6 or NFKB

  

GRP78

ATF6 or XBP1 or ATF4 and (not ER)

ATF6

GRP78

PERK

GRP78 and (not DNAJC3)

IRE1

BAX or BAK or GRP78

EIF2S1

GADD34 and (not PERK)

DNAJC3

ATF6 or XBP1

ATF4

EIF2S1

CHOP

ATF6 or ATF4

XBP1

IRE1

GADD34

CHOP

TNFR1

TNF α

TNFR2

TNF α

TRAF2

IRE1 or TNFR2 or TRADD

ASK1

OS or TRAF2 or DAXX

JNK

OS or ASK1 or GADD45

p38

OS or ASK1

BCL2

(not JNK) and (not CHOP) and (not P53) and (not BAD)

BID

CASP8 and (not BCL2)

BAX

JNK or P53 and (not BCL2)

BAK

BAX and (not BCL2)

DIABLO

BAX or BAK or BID

HtrA2

BAX or BAK or BID

FasR

FasL

TRADD

TNFR1

DAXX

FasR

RIPK1

FasR or TRADD

RAIDD

RIPK1

FADD

FasR or TRADD

CASP8

RAIDD or FADD or CASP3 or CASP6

CASP9

RAIDD or CASP8 or CASP3 or APAF1 or CASP12 and (not XIAP) and (not AKT)

CASP3

CASP9 or CASP8 and (not XIAP)

CASP7

CASP9 or CASP8 or CASP3 or CASP6 and (not XIAP)

CASP6

CASP7 or CASP3

  

XIAP

(not DIABLO) and (not HtrA2) (not CASP3)

CytochromeC

BAX or BAK or BID

APAF1

CytochromeC or P53

Apoptosis

CASP3 or CASP6 or CASP7

INS

INS

INSR

INS

IRS

INSR and (not SOCS3) and (not JNK) (not IKK β) and (not S6K)

PI3K

IRS or JAK

PIP3

PI3K

PDK1

PIP3

AKT

PDK1 or mTORC2 and (not TRB3)

AS160

AKT

PKC α

PDK1

GLUT4

AKT or AS160 or PKC α

GSK3 β

not AKT

GS

not GSK3 β

FOXO1

PERK and (not AKT) and (not XBP1)

PGC1 α

FOXO1

PEPCK

FOXO1

G6PC

FOXO1

PPAR α

PGC1 α

TRB3

PPAR α or CHOP

TSC1/2

(not AKT) and (not IKK β)

Rheb

not TSC1/2

mTORC1

Rheb

S6K

mTORC1

mTORC2

not S6K

BAD

JNK and (not AKT)

JAK

IL-6 and (not SOCS3)

STAT3

JAK

SOCS3

STAT3

IKK β

TRAF2

NF κB

not IKB α

IKB α

not IKK β