Fig. 4

Time to complete remission and duration of complete remission for a fast-pace leukemia. For the selected fast-pace leukemia we simulated all therapy-intensity combinations for the 7 + 3 combination therapy (range: 0–10) for both study arms. a and b show the days from diagnosis to CR. c shows the difference “Evaluation – Standard”. The gray areas show treatment intensities which lead to no CR (lower left area because of under- and upper right area because of overtreatment). The black lines represent selected contour lines (i.e.treatment intensities with same values). Considering a shorter time to CR as beneficial, a difference > 0 indicates a benefit for the standard arm. Differences < 0 indicate that the evaluation regimen is beneficial. Blue and red regions in the plot indicate where one of the two regimens allows for CR while the other does not, respectively. In particular, the blue area covers treatment combinations where the standard treatment leads to CR while the evaluation regimen already results in overtreatment. The red area shows that the evaluation regimen can be useful for low dose treatments. Here the evaluation and the second course allows to reach a CR where the standard regimen results in undertreatment. Plots d, e, and f display the CR duration. Due to the setup of the simulation no relapses occur thus simulation time after CR onset is considered. The difference between evaluation and standard shows two regions (red) where standard leads to longer CR durations. The green region shows where evaluation regimen allows for a CR while the standard arm does not