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Table 4 Case study results: the top ten predicted drugs for selected diseases

From: Computational drug repositioning using meta-path-based semantic network analysis

Disease Name

Known drugs (DrugBank IDs)

Top 10 ranked predictions

Huntington

OMIM ID: 143100

Baclofen (DB00181)

Tetrabenazine (DB04844)

Quetiapine (DB01224), Olanzapine (DB00334), Bupropion (DB01156), Clozapine (DB00363), Carbidopa(DB00190), Metyrosine(DB00765),

Phentermine (DB00191), Pethidine(DB00454), Phenelzine(DB00780) Donepezil (DB00843)

NSCLC

OMIM ID:211980

Doxorubicin (DB00997)

Daunorubicin (DB00694), Idarubicin (DB01177), Valrubicin (DB00385), Oxymorphone (DB01192), Anastrozole (DB01217), Oxycodone (DB00497), Buprenorphine (DB00921), Levobunolol (DB01210), Vincristine (DB00541), Carboplatin (DB00958)

AD

(OMIM ID: 104300)

Citalopram (DB00215),

Chlordiazepoxide (DB00475),

Acamprosate (DB00659),

Naltrexone (DB00704),

Disulfiram (DB00822),

Ondansetron (DB00904)

Galantamine (DB00674), Olanzapine (DB00334), Risperidone(DB00734), Escitalopram (DB01175), Terfenadine (DB00342), Alprazolam (DB00404) Diazepam (DB00829), Lorazepam (DB00186), Methimazole (DB00763), Mechlorethamine (DB00888)

SCLC

(OMIM ID: 182280)

Cisplatin (DB00515)

Methotrexate (DB00563)

Teniposide (DB00444)

Etoposide (DB00773)

Topotecan (DB01030)

Lithium (DB01356), Mechlorethamine (DB00888), Carboplatin (DB00958), Epirubicin (DB00445), Daunorubicin (DB00694), Doxorubicin (DB00997), Irinotecan (DB00762), Codeine (DB00318), Vinorelbine (DB00361), Frovatriptan (DB00998)

PSAB, (OMIM ID: 606581)

None

Citalopram (DB00215), Chlordiazepoxide (DB00475), Acamprosate (DB00659), Naltrexone (DB00704), Disulfiram (DB00822), Ondansetron (DB00904), Niacin (DB00627), Clofibrate (DB00636), Fenofibrate (DB01039), Gemfibrozil (DB01241)