Skip to main content
Fig. 5 | BMC Systems Biology

Fig. 5

From: Multi-component gene network design as a survival strategy in diverse environments

Fig. 5

Results of the competition experiment in Environment D (1% galactose). a Final expression level distributions of the 16 strains. b Average PGAL1-YFP expression level of the 16 strains. Expression levels are normalized to the expression level of the reference strain in the same sample. Error bars indicate s.e.m. (N = 9). Stars indicate statistically significant differences from wild-type strain as determined by a two-tailed Student’s t-test (Bonferroni-corrected p-value: ****: p < 0.0001; ***: p < 0.001; **: p < 0.01; *: p < 0.05). c Average fitness value of the 16 strains, normalized to the average fitness value of the wild-type strain. Error bars indicate s.e.m. (N = 9). Stars indicate statistically significant differences from wild-type strain as determined by a two-tailed Student’s t-test (Bonferroni-corrected p-value: ****: p < 0.0001; ***: p < 0.001; **: p < 0.01; *: p < 0.05). d Plot of expression vs. fitness for the 16 strains. Solid line is the prediction of the fitted linear model. The dotted, dashed, and dotted-dashed lines show the prediction of the model at 0.1%, 0.3% and 2% galactose, respectively. Error bars indicate s.e.m. (N = 9). e Average effect of copy number reduction on fitness for the four genes in this environment. Error bars indicate uncertainty calculated from the s.e.m. of the fitness measurements

Back to article page