Table 1 Some examples of SA bio-production systems using natural producers or metabolic engineered organisms
From: Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z
Organism | Genetic modifications | Culture conditions | Carbon sources (CS) | SA Yield (g.gCS−1) | References |
|---|---|---|---|---|---|
B. succiniciproducens | Anaerobic, continuous | Glycerol | 1.02 | [21] | |
M. succiniproducens | Anaerobic, batch | Glucose | 0.59 | [71] | |
M. succiniproducens | – Deletion of ldhA, pflB, pta, and ackA genes | Anaerobic, fed-batch | Glucose | 0.76 | [30] |
A. succinogenes | Anaerobic, continuous | Xylose | 0.80 | [63] | |
A. succinogenes | Anaerobic, batch | Glucose | 0.74 | [72] | |
A. succinogenes | Anaerobic, repeated fed-batch | Glucose | 0.88 | [31] | |
E. coli | – Deletion of pflB, ldhA, ppc genes – Heterologous expression of pckA from B. subtilis | Anaerobic, batch | Corn stalk hydrolysate | 1.02 | [43] |
E. coli | – Deletion of iclR, icd, sdhAB, ackA-pta, poxB – Heterologous expression of pepc gene from Sorghum vulgare | Aerobic, batch | Glucose | 0.72 | [73] |
S. cerevisiae | – Deletion of sdh3, ser3, ser33 – Overexpression of ICL1 | Aerobic, batch | Glucose | 0.05 | [37] |
S. cerevisiae | – Deletion of pdc1, pdc5, pdc6, fum1, gpd1 – Overexpression of pyc2, mdh3, fumC and frds1 | Aerobic, batch | Glucose | 0.14 | [19] |