Fig. 5

Donor variability in 3D experimental skin models with melanoma cells. Experimental images show metabolically active cells (light purple) on the 3D experimental skin model after four days. The skin models are constructed using primary skin cells and dermis from three different donor samples denoted a; b; and c. The scale bars are 1 mm. The melanoma nests are shown in dark purple. In each set of subfigures, (a-c), the images in the upper row show experiments initialised with 1250, 5000 and 8500 non-irradiated melanoma cells, respectively. In each set of subfigures, (a-c), the images in the lower row show experiments initialised with 1250, 5000 and 8500 irradiated melanoma cells, respectively