Skip to main content
Fig. 5 | BMC Systems Biology

Fig. 5

From: Petri net-based prediction of therapeutic targets that recover abnormally phosphorylated proteins in muscle atrophy

Fig. 5

A high-level procedure of Petri net simulations for three states and their results. a Common procedures for all of three states except for state-specific perturbations. b State-specific perturbations for each of three states. Before checking each transition, we give perturbations to relevant places according to each state. For the reference state, there is no perturbation. For the atrophic state, high activity is assigned to myostatin that induces muscle atrophy. For each gene-inhibited state, zero activity is assigned to each place on the atrophic state. c Simulation results. The final markings (the marking of 100th block) of the ten iterations were averaged to get the phosphorylation status for one reference, one atrophic and 331 gene inhibited states

Back to article page