Fig. 1
From: Nanog induced intermediate state in regulating stem cell differentiation and reprogramming
The stochastic gene regulatory model of cell fate determination with Nanog and lineage specifiers. a The five-node gene regulatory network of cell fate determination. The network includes three stemness genes: Oct4, Sox2, Nanog, and two mutual antagonistic lineage specifiers: MEs and ECTs. b and c The cell-state landscape of multiple cell attractors, produced from trajectory density sampling. The red-color regions indicate relatively high sampling probability, corresponding to low value of − log(P ss ) on potential landscape. b The five-dimensional phase space is transformed to three-dimensional one, where the x-axis represents the geometric average of Oct4 and Sox2, the y-axis for Nanog, and the z-axis indicates the difference between MEs and ECTs. c The landscape in a two-dimensional phase plane, where the MEs-ECTs axis is compressed. d Typical temporal trajectories of stochastic gene expression of stem cell state. Frequent dynamical transitions between high- and low-Nanog states can be seen (blue line)