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Fig. 7 | BMC Systems Biology

Fig. 7

From: Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology

Fig. 7

Impact of phenytoin on repeat oral dose estradiol kinetics in women. Estradiol venous blood concentrations were simulated for the 1495-person virtual population following a 0.5 mg, b 1 mg, or c 2 mg oral estradiol. A representative concentration-time plot is shown in the left panel, with AUC and trough concentration (mean ± s.d) presented in the middle and right panels, respectively. Statistical significance was assessed using a two-way ANOVA with Sidak’s multiple comparison test. *** = p < 0.001 compared to 0μM phenytoin

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BMC Systems Biology

ISSN: 1752-0509

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